Antibody tests can be conclusive 23 to 90 days after exposure. In general, antibody tests that use blood from a vein can detect HIV sooner after infection than tests done with blood from a finger Next generation point-of-care HIV testing Alere Determine™ HIV-1/2 Ag/Ab Combo is a 4th generation test earlier than 2nd and 3rd generation antibody-only tests.2 This enables health care providers to diagnose HIV seek medical care sooner. • CLIA waived for fingerstick whole blood. Requires minimal training. • Test in three easy steps. The HIV 4th Generation blood test can be taken 2-3 weeks after exposure and tests for HIV antibodies and HIV p24 antigens. The HIV RNA blood test is used for early detection of HIV's actual genetic material and can deliver accurate results after only 9-11 days post-exposure. 1.2 million Americans are HIV-positive (35 million people worldwide). The window period for HIV testing after completing PEP is a crucial consideration. Most guidelines recommend an test at the end of the PEP treatment and anothertest four to six weeks after completing PEP. However, the exact timing may vary depending on the type of test used and the specific circumstances of the individual. Because third-generation tests detect only antibodies to HIV, they cannot detect HIV infection during acute infection—the period after virus acquisition when viral protein (HIV-1 antigen) may be detectable but antibodies to HIV are not. 4 In contrast, fourth-generation HIV-1/2 testing methods can detect HIV-1 antigen as well as HIV-1 and HIV Serological tests based on the enzyme immunoassay (EIA) are the primary tool for the diagnosis of human immunodeficiency virus (HIV) in adults and have rapidly evolved to quicker, affordable and more accurate test formats to detect early HIV infection. Second- and third-generation HIV rapid tests detect the immunoglobulin G (IgG) and jIl4HrG.

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